Although each individual rare disease may impact only a small community of patients, according to the National Organization for Rare Disorders, more than 300 million people globally are affected by a rare disease. GemPharmatech offers an array of models and services to support the efforts of researchers working in rare diseases.

Knockout All Project

GemPharmatech’s Knockout All Project (KOAP) aims to generate knockout (KO) and conditional knockout (cKO) mouse strains for all ~23,000 protein coding genes in the mouse genome. Our specialized CRISPR-Cas9 platform can generate KO and cKO mice quickly and efficiently, enabling the production of over 6,000 new mutant strains annually with more than 17,000 strains created to date.

Learn more about the Knockout All Project.

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Customized Mouse Models Using CRISPR-Cas9 Technology

GemPharmatech constructs more than 6,000 customized mouse models per year utilizing CRISPR-Cas9 technology. Our technology platform allows us to create models more quickly and with greater success than traditional methods.

Learn more about our customized mouse models.

For non-profit organizations working in rare disease, GemPharmatech funds up to 85% of the cost of the creation of a custom model. Since 2020, GemPharmatech has created more than 85 custom models for rare diseases under this initiative.

Learn more about funding opportunities and apply.

Genetically Engineered Mouse Models for Rare Diseases — GemPharmatech