Building the world’s largest resource library of knockout (KO) and conditional knockout (cKO) mice

GemPharmatech’s ambitious Knockout All Project (KOAP) aims to generate knockout (KO) and conditional knockout (cKO) mouse strains for all ~23,000 protein coding genes in the mouse genome. Our specialized CRISPR-Cas9 platform can generate KO and cKO mice quickly and efficiently, enabling the production of over 6,000 new mutant strains annually. Nearly 8,000 genes have been successfully targeted thus far, providing KO and cKO mouse models for a wide array of research fields such as oncology, autoimmunity, metabolism, and neurodegeneration. KOAP aims to provide the best tool mice to our customers to accelerate biomedical discovery and drug development.

Key Advantages of GemPharmatech’s Knock Out All Project:

  • Largest collection of CRISPR mouse strains Over 17,000 available KO and cKO mouse strains with more in development
  • Customized construction of knockout mice and conditional knockout mice If a KO or cKO mouse strain is not yet available, one can be created in as little as 3-6 months
  • Access to our comprehensive services platform Phenotyping, drug efficacy testing, in vitro pathological analysis, and more
  • Quick, hassle-free customer service Orders can be placed online or with our expert sales representatives

protein subcellular localization of available ko and cko strains

Knockout All Project (KOAP)