Preclinical Study on Human NK-related in Humanized Mouse Model

February 24, 2023

NK cells (Natural Killer Cells) are bone-marrow-derived granular lymphocytes that are crucial in immune defense. In recent years natural killer (NK) cell therapy is becoming a rising star in oncology therapeutic development because of its advantages in effectiveness and safety compared to CAR-T treatment. However, limited in-vivo persistence and precise prediction of ADCC are challenges for NK cell therapies. At GemPharmatech, we strive to create animal models that will assist in elucidating the challenges that are currently faced in the NK cell therapy area. We developed NCG-hIL15 and NCG-IL2 mouse models, which can promote the reconstitution of human NK after huHSC engraftment, and supported the preclinical studies of CAR-NK or ADCC therapies. In this webinar, our scientist will introduce:

  • Limited persistence of NK cells and strategies in preclinical studies

  • Differences in clinical response of ADCC effect between animals and humans and corresponding solutions

PST 8:00 am | CST 10:00 am | EST 11:00 am | CET 17:00 pm, March 7th, 2023

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