Model animals, as an important tool for human disease research, aid in the investigation of disease mechanisms and the development of therapies. Mouse models, being the most extensively used model animals, are employed in a variety of areas, such as fundamental scientific research, drug discovery, preclinical evaluation, and clinical technology development. Mice have a close relationship with humans, advanced genetic manipulation, fast reproduction, and a clear genetic background. Gene editing technology can provide suitable disease models for study based on disease-related genes.GemPharmatech has produced numerous disease models using gene editing technologies, such as spontaneous tumor models, obesity models, diabetes models, Alzheimer's disease models, Parkinson's disease models, and so on. Through phenotypic analysis, GemPharmatech has also confirmed the incidence and development of numerous model-related phenotypes, providing solid support for the research of various diseases.