C57BL/6JGpt-Alkbh5em2Cd6815in34/Gpt
Alkbh5-KO|Strain NO.T003676
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Alkbh5em2Cd6815in34/Gpt |
| Strain Number: | T003676 |
| Official Symbol: | Alkbh5 |
| Strain Strategy: | T003676.Alkbh5 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | alkB homolog 5, RNA demethylase |
| Also Known As: | AW050020,AW215868,Abh5,E130207K11,Ofoxd |
| NCBI Number: | 268420 |
| MGI Number: | 2144489 |
| Chromosome: | 11 |
| Deletion (size): | -6815bp+34bp |
| Research Areas: | Developmental Biology,cell differentiation,Physiological system,reproductive system,endocrine/exocrine glands,Cell biology,cellular,Cell localization,Golgi apparatus,cell nucleus,Molecular biology,DNA methylation,oxidordeuctase |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T003676.Alkbh5 Genotyping Protocol(KO).pdf |
| Inventory Status: | Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A2. Inhibition of ALKBH5 attenuates I/R-induced renal injury in male mice by promoting Ccl28 m6A modification and increasing Treg recruitment3. m(6)A demethylase ALKBH5 attenuates doxorubicin-induced cardiotoxicity via posttranscriptional stabilization of Rasal34. ALKBH5 controls the meiosis-coupled mRNA clearance in oocytes by removing the N (6)-methyladenosine methylation |
| Gene Family: | Alkylation repair homologs |