C57BL/6JGpt-Nlrp3em7Cd4411/Gpt
Nlrp3-KO|Strain NO.T010873
Knockout (KO)
- Product Type:
- Quantity: - +
- Sex:
- Age:
- Genotype:
BASIC INFORMATION
| Strain Name: | C57BL/6JGpt-Nlrp3em7Cd4411/Gpt |
| Strain Number: | T010873 |
| Official Symbol: | Nlrp3 |
| Strain Strategy: | T010873. Nlrp3 Cas9-KO Strategy-EN.pdf |
| Official Full Name: | NLR family, pyrin domain containing 3 |
| Also Known As: | AGTAVPRL,AII/AVP,Cias1,FCAS,FCU,MWS,Mmig1,NALP3,Pypaf1 |
| NCBI Number: | 216799 |
| MGI Number: | 2653833 |
| Chromosome: | 11 |
| Deletion (size): | -4411bp |
| Research Areas: | Metabolic research,adipose tissue,Protein metabolism,homeostasis/metabolism,Developmental Biology,cell differentiation,growth/size/body,mortality/aging,immune system,Inflammation,nervous system,Physiological system,integument,skeleton,reproductive system,digestive/alimentary system,liver/biliary system,renal/urinary system,hematopoietic system,limbs/digits/tail,Cell biology,Cell death,cellular,Cell localization,endoplasmic reticulum,Golgi apparatus,cell nucleus,Molecular biology,Signal Transduction,DNA transcription,DNA binding protein |
| Strain Background: | [N000013] C57BL/6JGpt |
| Modification Type: | Knockout (KO) |
| Genotyping Protocols: | T010873.Nlrp3 Genotyping Protocol(KO).pdf |
| Inventory Status: | Live,Cryopreserved |
| Sale Status: | IF (Available for Distribution) |
| Health Status: | Specific pathogen free (SPF) |
| Publications: | 1. Berberine augments hypertrophy of colonic patches in mice with intraperitoneal bacterial infection2. Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways3. Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic gossypol4. Mitochondrial Dysfunction by FADDosome Promotes Gastric Mucosal Injury in Portal Hypertensive Gastropathy |
| Gene Family: | NLR familyPyrin domain containing |