Transgenic Mice for in vivo Genome Modification

Knockout & Conditional Knockout Mouse Models
Signaling Pathways Gene Family Live Knockout Mice & Conditional Knockout Mice
Disease Mouse Models
Autoimmune Disease ModelsMetabolic Disease Mouse ModelsRare Disease Mouse ModelsNeurodegenerative Disease Mouse ModelsImmuno-Oncology Mouse Models
Germ-Free Mouse Models
Tool Mice
Cre/Dre Mice Transgenic Mice for in vivo Genome ModificationReporter Mice
Immunodeficient Mouse Models
NCG ModelsNext-Gen NCG ModelsOther Immunodeficient Strains
The Wild Mouse Project
Wild Mouse 750Wild Mouse 765
NeoMab™ Antibody Fully-Humanized Mouse Models

We provide transgenic strains which express Cas9 endonuclease and tdTomato fluorescence indicator in a constitutive (T004285) or Cre-dependent (T002249) manner. These strains can be applied with sgRNA-expressing transgenic mouse strains or viral vectors to achieve genome modification in vivo.

Strain No.
 Strain Name Strain Type Description
T002249 Rosa26-CAG-LSL-Cas9-tdTomato KI This strain can be used for genetic function and oncology research after in vivo knockout/knock-in of single or multiple genes.
T004285 B6-CAG-cas9-tdTomato KI This strain can be used for genetic function and oncology research after in vivo knockout/knock-in of single or multiple genes.