Syngeneic Cell Lines

GemPharmatech has an extensive collection of syngeneic cell lines, including murine-derived cells and genetic modification of the corresponding cells, as well as several popular target cells, including PDL1, CD47, CD73, CD19, CD20, CD33, EGFR, HER2, BCMA, etc., providing a rich resource of tumor models for immune checkpoint drug efficacy evaluation.

Cancer Type	Cell Line	Background	Engineered Human or Mouse Target	Availability
Colorectal	CT26	BALB/c	hPDL1(Tg)-mPDL1(KO)	Available
Colorectal	CT26	BALB/c	hCD47 (Tg)-mCD47(KO)	Available
Colorectal	CT26	BALB/c	hPDL1(Tg)-mPDL1(KO)-hCD47(Tg)-mCD47(KO)	Available
Colorectal	CT26	BALB/c	hPDL1(Tg)-mPDL1(KO)-hCD73(Tg)-mCD73(KO)	Available
Colorectal	CT26	BALB/c	hPDL1(Tg)-mPDL1(KO)-hCD39(Tg)-mCD39(KO)	Available
Colorectal	CT26	BALB/c	hNectin4 (Tg)-mNectin4(KO)	Available
Colorectal	CT26	BALB/c	hPDL1(Tg)-mPDL1(KO)-hB7H3(Tg)-mB7H3(KO)	Available
Colorectal	CT26	BALB/c	hROR1(Tg)-mROR1(KO)	Available
Colorectal	CT26	BALB/c	hPDL1(Tg)-mPDL1(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO）	Available (Cell only)
Colorectal	CT26	BALB/c	hCD47(Tg)-mCD47(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO）	Available (Cell only)
Colorectal	MC38	C57BL/6	hPDL1(Tg)-mPDL1(KO)	Available
Colorectal	MC38	C57BL/6	hCD47 (Tg)-mCD47(KO)	Available
Colorectal	MC38	C57BL/6	hPDL1(Tg)-mPDL1(KO)-hCD73(Tg)-mCD73(KO)	Available
Colorectal	MC38	C57BL/6	hPDL1(Tg)-mPDL1(KO)-hB7H3(Tg)-mB7H3(KO)	Available
Colorectal	MC38	C57BL/6	hPDL1(Tg)-mPDL1(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)	Available (Cell only)
Colorectal	MC38	C57BL/6	hCD47(Tg)-mCD47(KO)-hCD24A(CD24)(Tg)-mCD24A(CD24)(KO)	Available (Cell only)
Breast	EMT6	BALB/c	hPDL1(Tg)-mPDL1(KO)	Available
Breast	EMT6	BALB/c	hCD39(Tg)-mCD39(KO)	Available
Melanoma	B16F10	C57BL/6	hPDL1(Tg)-mPDL1(KO)	Available
Liver	H22	BALB/c	hPDL1(Tg)-mPDL1(KO)-hCD47(Tg)-mCD47(KO)	Available
Liver	H22	BALB/c	hPDL1(Tg)-mPDL1(KO)
Colorectal	CT26	BALB/c	None	Available
Liver	H22	BALB/c	None	Available
Breast	4T1	BALB/c	None	Available
Breast	EMT6	BALB/c	None	Available
Lymphoma	A20	BALB/c	None	Available
Lymphoma	MPC-11	BALB/c	None	Available
Lymphoma	J558	BALB/c	None	Available
B lymphocyte	BcL1 clone 5B1b	BALB/c	None	Available
Renal	RENCA	BALB/c	None	Available
Leukemia	WEHI-3	BALB/c	None	Available
Embryonal Carcinoma	NFPE	BALB/c	None	Available
Colorectal	MC38	C57BL/6	None	Available
Lung	LLC1	C57BL/6	None	Available
Pancreas	PAN02	C57BL/6	None	Available
Melanoma	B16F0	C57BL/6	None	Available
Melanoma	B16F1	C57BL/6	None	Available
Melanoma	B16F10	C57BL/6	None	Available
Breast	MMT 060562	C57BL/6	None	Available
Breast	E0771	C57BL/6	None	Available
Lymphoma	YAC-1	C57BL/6	None	Available
Lymphoma	E.G7-OVA	C57BL/6	None	Available
Lymphoblast	C1498	C57BL/6	None	Available
B lymphocyte	HOPC 1F/12	C57BL/6	None	Available
Prostate	RM-1	C57BL/6	None	Available
Sarcoma	SaI/N	TBD	None	Available
Bladder	MB49	TBD	None	Available

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