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Signaling Pathways

DNA Methylation

Cells use DNA methylation, which is an epigenetic mechanism that transfers a methyl group to the C5 position of the cystine ring on DNA, to control their gene expression. Methylation is typically used to repress gene transcription or “turn off” genes.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.