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Signaling Pathways

Epigenetic Histone H3

Of the five identified histones, histone 3 (H3) has a long N-terminal tail and a main globular domain and is the most widely modified (e.g., phosphorylated) and plays a critical role in dynamic and long-term regulation of genes. 

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.