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Signaling Pathways

Dopamine Parkinsons

Dopamine synthesis involves several enzymes and cofactors. In healthy conditions tyrosine is converted to levodopa, which is then metabolized to dopamine. In the presence of Parkinson’s several pathways are affected, including dopamine synthesis, which is significantly reduced.

The pathway below is interactive, meaning you can click on an active pathway component (highlighted in orange) to learn more about available mouse models relevant to that specific gene and pathway function.